Webb1 okt. 2016 · The NRG Oncology TNT clinical trial (NRG-GI002) is a randomized phase II platform study with parallel, non-comparative experimental arms with a single comparative control arm of neoadjuvant chemotherapy and chemoRT in locally advanced and high-risk rectal cancer (see Figure 1). Webb29 apr. 2024 · A large phase II multicentered randomized trial is also ongoing investigating the efficacy of TNT and a selective nonoperative approach in locally advanced rectal cancer. 71 In this trial, patients are randomly assigned to either an induction chemotherapy or a consolidation chemotherapy group.
Rectal Cancer Memorial Sloan Kettering Cancer Center
Webb13 maj 2024 · Once a rectal cancer is diagnosed via colonoscopy or digital rectal examination, a CT of the torso to assess for metastatic disease, as well as MRI of the pelvis for tumor and nodal staging, should be performed. 3 , 4 , 5 More than half of all rectal cancers present as stage II or stage III disease. Webb1 mars 2024 · Based on literature data suggesting promising advantages of total neoadjuvant therapy (TNT), we performed a retrospective, single-arm, single-center study on 45 patients affected by histologically and radiologically proven locally advanced rectal cancer, with the aim of analyzing the feasibility and short-term efficacy of an integrated … ufo search bozeman
Organ preservation and total neoadjuvant therapy for rectal cancer …
Webb4 aug. 2024 · A two-step approach is recommended, involving initial measurement at 12 weeks from the start of treatment and then, in patients with a near clinical complete response (ncCR) at initial... Webb12 apr. 2024 · In the very recently published OPRA trial, 324 patients with stage II/III rectal cancer were randomized to receive TNT with concurrent lcCRT followed by … Webb17 juni 2024 · TNT allows the opportunity to improve both distant disease control in rectal cancer and locoregional morbidity through organ preservation, which has not yet … ufo season 1 showtime