WebMar 27, 2024 · IL-4 is the critical Th2 cytokine responsible for Th2 cell differentiation which it does via a STAT6-dependent pathway. However, Th2 cell differentiation also occurs via a STAT6-independent pathway, involving STAT5 and IL-2 receptor signaling. WebJun 19, 2024 · Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), chronic inflammation and tissue remodeling ( 1 ). The majority of cases of asthma are associated with IgE-mediated reactions reflecting atopy due to the critical role IgE plays in the development of asthma ( 2 ).

Inflammatory Cells Involved in Asthma SpringerLink

WebMar 15, 2002 · The human signal transducer and activator of transcription 6 (STAT6) gene represents one of the most promising candidate genes for asthma and other inflammatory diseases on the chromosomal region 12q13–q24.Therefore we screened all 23 exons, including parts of the neighbouring introns, as well as the promoter region for common … WebInterleukin-4 (IL-4) is a cytokine that plays a crucial role in the pathophysiology of asthma and allergic diseases. IL-4-induced gene expression is largely mediated through the activation of the latent transcription factor STAT6. We identified a STAT6 mutant (STAT6VT)) that is activated independently of IL-4 stimulation. STAT6VT carries two … disciplinary images

National Center for Biotechnology Information

Webment of asthma. However, the interaction between SNPs in the IL-4 / IL-13 signalling pathway is of greater impact. Hypermethylation of the STAT6 promoter is also significant in the regulation of STAT6 expression and this fact opens possibilities for targeting therapy in asthma. Key words: IgE, atopy, asthma, polymorphisms, haplotypes, STAT6 ... WebSTAT6 is the only STAT protein that prefers binding to DNA motifs with a N4 spacer. One STAT6 homodimer binds a palindromic DNA motif. Each monomer binds half of the palindromic sequence. Residues at in the DBD participate in the recognition and binding of the palindromic DNA motif. WebNov 21, 2014 · Introduction. Allergic asthma is a chronic inflammatory disorder of the airway, driven by an imbalance in T helper (Th) cell responses, leading to chronic airway inflammation, fibrosis in the lamina reticularis and adventitia of the airway, and mucus hypersecretion in the lung .Overactive Th2 responses drive the development of asthma by … fountainful