Web22 dec. 2008 · On the other hand, menadione is a multivitamin component and a therapeutic agent for hypothrombinemia and cancer. Its cytotoxic mechanism has been associated with the excessive generation of ROS such as superoxide radicals, singlet oxygen, and hydrogen peroxide. WebThus, these results show that menadione causes ROS generation and high accumulation of cellular ROS levels, which affects cell viability and cell morphology and there is a …
Menadione-induced Reactive Oxygen Species Generation …
WebData analysis and graphing were performed in GraphPad Prism. Results Menadione is known to interrupt the mitochondrial electron transport chain, causing ROS accumulation. Menadionetreated HepG2 cells showed a concentration-dependent increase in ROS indicated by increased luminescence (Figure 1). WebOxidative stress results from the action of ROS, short-lived oxygen-containing molecules with high chemical reactivity toward lipids, proteins, and nucleic acids. Until recently, ROS were regarded as merely damaging agents, but are now recognized as second messengers that regulate cellular function through oxidant signaling ( 8, 9 ). first covid tests in 2020
Measuring reactive oxygen species with SpectraMax microplate …
WebMenadione generated ROS with a concomitant decrease of NAD (P)H, consistent with redox cycling. The elevation of ROS was prevented by the antioxidant N -acetyl- l … Web14 apr. 2024 · Protein targets that are affected by ROS and underly impaired inotropic effects in the heart are largely unknown. Here, the authors identify the γ-subunit of IDH3 as a redox switch linking ... Web10 dec. 2008 · Read "Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation, Apoptosis" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. ev clearscan re2 transmitter