Hemojuvelin antibody
WebHuman RGM-C/Hemojuvelin Antibody Summary Species Reactivity Human Specificity Detects human RGM-C/Hemojuvelin in direct ELISAs. Source Monoclonal Mouse IgG 2B Clone # 751741 Purification Protein A or G purified from cell culture supernatant Immunogen Mouse myeloma cell line, NS0-derived human RGM-C/Hemojuvelin Gln36-Asp400 … WebHemojuvelin, An Anchored Membrane Protein Stimulates Hepcidin Transcription Through Bone Morphogenic (Morphogenetic) Proteins and Smad. HJV (also named RGMc or HFE2) is a regulator of hepcidin production. It is tethered to the cell membrane by a …
Hemojuvelin antibody
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WebListed below are anti-Hemojuvelin antibodies from multiple suppliers. Hemojuvelin is a reported alias name for the human gene HJV, or 'hemojuvelin BMP co-receptor'. The 426-amino acid protein is a member of the Repulsive guidance molecule (RGM) family. The … WebOct 10, 2024 · The BMP-6–hemojuvelin (HJV, a BMP co-receptor) complex can bind to heterodimeric BMP receptors (BMPRs) composed of type I (BMPRI; ALK1, ALK2, ALK3 and ALK6) and type II (BMPRII, ACTRIIA and ACTRIIB) serine threonine kinase receptors. ... USA) and anti-SMILE (Zhangfei, 1:1000 or 1:3000 dilution; Abcam, Cambridge, UK). …
WebThis antibody functions as an ELISA capture antibody when paired with Mouse Anti-Human RGM‑C/Hemojuvelin Monoclonal Antibody (Catalog # MAB37201). This product is intended for assay development on various assay platforms requiring antibody pairs. WebHemojuvelin, also known as HFE2, is a membrane-bound and soluble protein that belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homolog of the Netrin receptor deleted in colon cancer.
WebNov 15, 2024 · Introduction DISC-0974 is a humanized monoclonal antibody against hemojuvelin (HJV) and is currently in Phase I clinical studies. HJV is a pathway-specific coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism. Loss of function mutations of the HFE2 gene encoding … WebProduct name Anti-Hemojuvelin antibody [C1] See all Hemojuvelin primary antibodies Description Mouse monoclonal [C1] to Hemojuvelin Host species Mouse Tested applications Suitable for: IHC-P, WB more details Species reactivity Reacts with: Rat, Human, Pig Immunogen
WebThe hemojuvelin antibodies are effective in suppressing hepcidin and increasing hemoglobin (Hb) in inflammatory and non-inflammatory states caused by excess hepcidin and represent new therapeutic candidates for patients suffering from ACD and IRIDA.
WebThere are no reviews for RGM-C/Hemojuvelin Antibody (H00148738-M01). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- … house foreclosure in mdWeb检测原理： 攸碧艾（YOBIBIO)的ELISA试剂盒采用“夹心法”:将捕获抗体包被于酶标板上，捕获样品及标准品中的靶蛋白，生物素化的检测 S house foreign affairs committee gop twitterWebMar 31, 2024 · DISC-0974: Anti-Hemojuvelin Antibody (Hepcidin Suppression) DISC-0974 is an investigational anti-hemojuvelin monoclonal antibody (mAb) and is designed to suppress hepcidin production and... linux change to root directoryWebSignaling of BMP6 is driven by a co-receptor molecule, RGMc, also known as hemojuvelin. Utilizing our structural biology insights into BMP6 and its co-receptors, along with our novel antibody discovery and optimization strategies, we have identified specific inhibitors of RGMc’s interaction with BMP6. house foreclosure near meWebOct 15, 2005 · The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels of hepcidin, the principal iron-regulatory hormone secreted by the liver. linux change to super userWebMay 15, 2024 · This two-site enzyme-linked immunosorbent assay was highly specific for mouse hemojuvelin, with a lower limit of detection at … linux change user and group recursivelyWebNew Antibodies to Phospho Alpha Synuclein and Tau; Pre-made AAV Center; New Fast Genetically Encoded Calcium Indicators: jGCaMP8; New Fluorescent Probes for Detection of Neurotransmitters: GRAB Probes; One-Stop Solution for Inducing iPS Differentiation into Neurons; Latest Advancements. Current Therapeutic Targets for Alzheimer's Disease ... house for auction stoke on trent