Ddit4 hypoxia
WebMar 2, 2024 · Hypoxia induces acute transactivation and repression in a HIF1A-dependent manner, but only transactivation is associated with HIF1A binding. Repressed genes are enriched for MYC targets, which... WebFeb 14, 2024 · DNA damage-inducible transcript 4 (DDIT4) has a role in human squamous cell carcinoma and is a molecular vector for the anti-carcinoma effect of 1,25(OH)2 D3 The present study clearly demonstrated that Redd1 is a therapeutic target in the development of heart failure after myocardial infarction.
Ddit4 hypoxia
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WebFeb 12, 2016 · DDIT4 expression is low in physiological condition but is induced and plays an important role in hypoxia, oxidative stress, DNA damage, and other stimuli [13, 14]. It has been reported that DDIT4 can induce hypoxia-triggered apoptosis of differentiated PC12 cells through activation of the caspase pathway . WebJan 8, 2024 · DDIT4 stabilizes the formation of tuberous sclerosis complex 1 (TSC1) and 2 (TSC2) to inhibit activation of the mammalian target of rapamycin (mTOR) complex (mTORC)-1, leading to cell death [ 7 ]. It seems that DDIT4 may have a tumor-suppressive role in cancer progression.
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WebJan 22, 2024 · DDIT4 is a highly conserved stress response protein whose expression is affected by various cellular stresses, such as hypoxia, DNA damage, energy stress, nutrient depletion, and endoplasmic reticulum stress [ 8 ]. WebDDIT4 located on chromosome 10 (10q22.1) is ubiquitously expressed at low levels in most adult tissues 31 but is downregulated in a subset of human cancers. 32,33 REDD1 is induced by various stress conditions, including hypoxia, 31 energy depletion, 34 oxidative stress, 35 and endoplasmic reticulum stress. 36 REDD1 has been shown to inhibit ...
WebRegulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it …
WebHypoxia downregulates DIMT1, and hypoxia‐induced miR‐210 suppresses DIMT1 and IRF4 in MM To validate whether chronic hypoxia could induce reduction in DIMT1 … swaping out bathtub faucetWebXiaoyu Deng is an academic researcher from Zhengzhou University. The author has contributed to research in topic(s): Nasopharyngeal carcinoma & DDIT4. The author has co-authored 2 publication(s). swaping a front wheel drive 5.3 to a truckWebDec 1, 2024 · In addition, Rnf182 is one of the hypoxia-induced upregulated genes and is related to cell migration and invasion (Iwasaki et al., 2024). The genes that appear more frequently are DNA-damage-inducible transcript 4 (ddit4) and CBP/p300-interacting transactivator with Glu/Asp-rich C-terminal domain 2 (cited2). skip wilson orofinoWebMay 5, 2024 · Furthermore, IL-10 suppresses mammalian target of rapamycin (mTOR) activity through the induction of an mTOR inhibitor, DDIT4. Consequently, IL-10 promotes mitophagy that eliminates dysfunctional mitochondria characterized by low membrane potential and a high level of reactive oxygen species. swaping prim+ to normal serverDDIT4 acts as a negative regulator of mTOR, a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In particular, upregulation of HIF-1 in response to hypoxia upregulates DDIT4, leading to activation of Tsc1/2 via 14–3–3 shuttling and … See more DNA-damage-inducible transcript 4 (DDIT4) protein also known as protein regulated in development and DNA damage response 1 (REDD1) is a protein that in humans is encoded by the DDIT4 gene See more Clinical interest in DDIT4 is based primarily on its effect on mTOR, which has been associated with aging and linked with diseases such as tuberous sclerosis, See more • Ellisen LW (November 2005). "Growth control under stress: mTOR regulation through the REDD1-TSC pathway". Cell Cycle. 4 (11): 1500–02. doi:10.4161/cc.4.11.2139. PMID 16258273. • Hartley JL, Temple GF, Brasch MA (November 2000). See more • HIF1A • Tuberous sclerosis protein • MTOR • 14-3-3 protein See more swaping ps3 hdd without formatWebREDD1 (regulated in development and DNA damage response 1) is a direct transcriptional target of HIF. It plays a role in the TSC/mTOR pathway as a regulator upstream of the TSC1/2 complex. In response to both hypoxia … swaping of two values programingWebDDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the … swaping phone cameras