2024 D-isomer specific 2-hydroxyacid dehydrogenase

D-isomer specific 2-hydroxyacid dehydrogenase

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WebFeb 17, 2024 · PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179; Ser-181 and Ser-185. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation (By similarity). SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. WebD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain . Other. 1 CDSs DB identifier Length Chromosome Location Organism . Name SapurV1A.0142s0080.1_CDS: …

PhytoMine: Protein SapurV1A.0142s0080.1.p S. purpurea v1.0

WebDec 1, 2000 · D-Lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family J. Biol. Chem. , 266 ( 1991 ) , pp. 12588 - 12594 View PDF View article View in Scopus Google Scholar WebDec 1, 2011 · Human GHPR is involved in the d-isomer-specific 2-hydroxyacid dehydrogenase family and structural studies identified key amino acid residues that are involved in substrate binding and in catalytic reactions [28]. His329 located in the active site is predicted to function as an acid/base catalyst to form a hydrogen bond with carbonyl … tms nsw login

Classification, substrate specificity and structural features …

WebD-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (2-Hacid_dh_C) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain: This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389. WebSep 23, 2015 · Hydroxyacid dehydrogenases are responsible for the conversion of 2-keto acids to 2-hydroxyacids and have a wide range of biotechnological applications. In this study, a D-lactate dehydrogenase (D-LDH) from a Sporolactobacillus inulinus strain was experimentally verified to have both the D-LDH and glutamate dehydrogenase (GDH) … WebJul 5, 1991 · In contrast, the D-lactate dehydrogenase is homologous to E. coli D-3-phosphoglycerate dehydrogenase and Lactobacillus casei D-2-hydroxyisocaproate … tms nottingham uk

Structural characterization of a D-isomer specific 2-hydroxyacid ...

WebThe sequence showed that HPPR belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases. The HPPR-cDNA was heterologously expressed in Escherichia coli and the protein was shown to catalyse the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to … WebOct 8, 2013 · Genetic and molecular analysis indicated that the ARA gene encodes a protein with a D-isomer specific 2-hydroxyacid dehydrogenase domain. ARA is expressed in all plant organs and is localized in the cell periphery. The ara mutant phenotypes can be rescued by exogenously applied Hse, Met, Ile and 2-oxobutanoate. Based on the results … tms new castle paWeb2-HYDROXYACID DEHYDROGENASE-RELATED -- 29 307 7.9E-68 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IPR006140: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain 103 274 1.4E-40 PANTHER PTHR10996:SF261 NAD-DEPENDENT 2-HYDROXYACID … tmsntf2

"WebJun 12, 2010 · Both the two proteins are D-isomer specific 2-hydroxyacid dehydrogenase and belong to NADB_Rossmann superfamily. The amino acid sequence of LdhD-1 shows a high identity (91.3%) to a well-characterized protein, HicDH, which is known to be responsible for D-LA formation in L. casei (Dengler et al. 1997; Viana et al. 2005). … " - D-isomer specific 2-hydroxyacid dehydrogenase

D-isomer specific 2-hydroxyacid dehydrogenase

WebJan 5, 2024 · HPR3 D-isomer specific 2-hydroxyacid dehydrogenase family protein [ (thale cress)] Gene ID: 837811, updated on 5-Jan-2024. Summary. Encodes a hydroxypyruvate reductase that reduces HP to glycerate and shows even more activity with glyoxylate, a more upstream intermediate of the photorespiratory cycle. It is likely … WebHere, we report the apo and coenzyme NAD⁺ complexed crystal structures of the L. bulgaricusD-isomer specific 2-hydroxyacid dehydrogenase, D2-HDH. Comparison …

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WebD-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 NAD(P)-binding domain superfamily; UniProtKB:F1QYH7. InterPro 361: … WebBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Curated. Phylogenomic databases. HOGENOM. CLU_019796_1_1_6; InParanoid. P52643; OMA. VIVTAHQ; OrthoDB. 9805416at2; PhylomeDB. ... PTHR43026:SF1 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED 1 hit; PROSITE. View protein in …

WebMAJ_08920 D-isomer specific 2-hydroxyacid dehydrogenase family protein [] Gene ID: 26278502, discontinued on 27-Feb-2024. Summary. Gene provides a unified query … WebLactic acid is a naturally occurring substance with the standard chemical name 2-hydroxy propionic acid. It is the simplest hydroxyl acid with an asymmetric carbon atom, and has …

WebD-isomer Specific 2-hydroxyacid Dehydrogenase Family Protein. Chemicals and Non-standard biopolymers (3 molecules) 1. 2. DI(HYDROXYETHYL)ETHER. 2. 1. TRIETHYLENE GLYCOL * Click molecule labels to explore molecular sequence information. Citing MMDB. Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer … WebMay 4, 2016 · D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Structure domains: NAD(P)-binding Rossmann-like Domain. Ligands and Environments 3 bound ligands: 2 x NAD. 2 x AZI. 2 x CL. No modified residues.

WebD-lactate dehydrogenase belongs to the D-isomer-specific 2-hydroxyacid dehydrogenase family. Packaging. 500, 2500, 5000 units in glass bottle. Biochem/physiol Actions. D-lactic dehydrogenase enzyme is required for the production and metabolism of D-lactate. D-lactate is metabolized to pyruvate with the help of lactic dehydrogenase …

WebAug 25, 1993 · Two His residues, His-205 and His-296, in Lactobacillus plantarum D-lactate dehydrogenase are highly conserved in the D-isomer-specific 2-hydroxyacid dehydrogenase family, suggesting that they are candidates for the catalytic His in the enzyme. The substitution of His-296 with Tyr by means of site-directed mutagenesis … tms nucorWebD-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D-lactate dehydrogenase gene of Lactobacillus plantarum. Source: J. Biol. Chem. 266:12588-12594(1991). PubMed ID: 1840590: 4: tmsoanrWebD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Provide feedback. This family represents the largest portion of the catalytic domain of 2-hydroxyacid … tms neuropathyWebGene ID: 44998042, updated on 9-Sep-2024. Summary Other designations. D-isomer specific 2-hydroxyacid dehydrogenase family protein tmsoandaWebD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain . Other. 1 CDSs DB identifier Length Chromosome Location Organism . Name SapurV1A.0142s0080.1_CDS: 1164 chr14: 12147106-12151266: Salix purpurea: 19 Ontology Annotations ... tmsntf2 casWebThe predicted PPR protein had sequence similarity to proteins in the d-isomer-specific 2-hydroxyacid dehydrogenase family. Phylogenetic analyses indicated that the predicted PPR protein together with fungal predicted proteins constitutes a novel group of glyoxylate/hydroxypyruvate reductases. The fungus efficiently converted phenylalanine … tms nt govWebFeb 1, 2013 · The resulting 333-residue protein, D2-HDH, is annotated to encode a D-isomer specific 2-hydroxyacid dehydrogenase (van de Guchte et al., 2006). Although the D2-HDH protein has not directly been characterized beyond this automatic functional annotation, a 99% homologous enzyme has been sequenced, cloned and its substrate … tms nutrition